| 货号 | MAB30551-SP |
| 别名 | EC 2.7.10; EC 2.7.10.1; insulin receptor-related protein; insulin receptor-related receptor; IRR; IRRIR-related receptor | 全称 | Insulin Receptor-related Receptor |
| 反应种属 | Human |
| 应用 | Western Blot(1 µg/mL) |
| 目标/特异性 | Detects human INSRR in direct ELISAs and Western blots. In direct ELISAs and Western blots, no cross‑reactivity with recombinant human Insulin receptor is observed. |
| 使用方法 | Western Blot: 1 µg/mL |
| 来源 | Reconstitute at 0.5 mg/mL in sterile PBS. |
| 产品组分 |
| 供应商 | R&D Systems |
| Entrez Gene IDs | 3645 (Human); 23920 (Mouse) |
| 应用文献 | |
| R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions. Expression profiling of the ovarian surface kinome reveals candidate genes for early neoplastic changes. | |
| 纯化方式 | Protein A or G purified from hybridoma culture supernatant |
| 免疫原 | Mouse myeloma cell line NS0-derived recombinant human INSRR Leu24-Leu923 Accession # P14616 |
| 生物活性 | Human |
| 标记 | Unconjugated |
| 溶解方法 | Reconstitute at 0.5 mg/mL in sterile PBS. |
| 背景 | INSRR is a 175 kDa orphan receptor belonging to the insulin receptorsubfamily of the receptor tyrosine kinase family.It is expressed in neuroblastoma and many adult tissues,including kidney, heart, pancreas, liver and skeletal muscle. INSRR is synthesized asa single chain type I transmembrane glycoprotein precursor andundergoes proteolytic processing to generate the mature disulfidelinked alpha 2/ beta 2 tetrameric receptor. The alpha subunit is localizedextracellularly while the transmembrane beta subunit contains anextracellular domain, a transmembrane segment and a cytoplasmic kinasedomain. Theextracellular domain of human INSRR shares approximately 90% amino acidsequence identity with the mouse protein. |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 参考文献 |
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