Human FGF R2 (alpha isoforms) MAb (Clone 98706) (25 UG)
货号：
MAB6841-SP 基本售价：
1467.3 元 规格：
-
产品信息
概述| 货号 | MAB6841-SP |
| 别名 | FGF R2 alpha; FGFR2a |
全称 | Fibroblast Growth Factor Receptor 2 alpha | | 反应种属 | Human |
| 应用 | Western Blot |
| 目标/特异性 | Detects human FGF R2 alpha in direct ELISAs and Western blots. Recognizes an epitope within the first Ig-like domain that is present only in alpha isoforms of human FGF R2. Does not cross-react with alpha isoforms of recombinant mouse FGF R2. |
| 使用方法 | Western Blot: 1 µg/mL
|
| 来源 | Reconstitute at 0.5 mg/mL in sterile PBS. |
| 产品组分 | |
性能| 供应商 | R&D Systems |
| Entrez Gene IDs | 2263 (Human); 14183 (Mouse) |
| 应用文献 |
| R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions. FGFR2-amplified gastric cancer cell lines require FGFR2 and Erbb3 signaling for growth and survival.
Authors: Kunii K, Davis L, Gorenstein J, Hatch H, Yashiro M, Di Bacco A, Elbi C, Lutterbach B
Cancer Res., 2008;68(7):2340-8.
Species: Human
Sample Type: Cell Lysates
Application: IP |
| 纯化方式 | Protein A or G purified from ascites |
| 免疫原 | S. frugiperda insect ovarian cell line Sf 21-derived recombinant human FGF R2 isoforms and Mouse myeloma cell line NS0-derived recombinant human FGF R2 isoforms |
| 生物活性 | Human |
| 标记 | Unconjugated |
| 溶解方法 | Reconstitute at 0.5 mg/mL in sterile PBS. |
| 背景 | FGF activity is mediated by a family of type I transmembrane tyrosine kinases, which undergo dimerization and autophosphorylation after ligand binding. Five distinct genes encode closely related FGF receptors, FGF R1 through 5. FGF Rs contain three Ig-like domains and a stretch of acidic residues between the first and second Ig-like domains. FGF R1, 2, 3, and -4 have a cytoplasmic split tyrosine-kinase domain, but FGF R5 does not. Multiple forms of FGF R1, 2, and 3 are generated by alternative splicing |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 参考文献 | - FGF Family
- FGF Ligands
- FGF Regulators
- Fibroblast Growth Factor Superfamily
- Fibroblast Growth Factors and their Receptors
- Glial Lineage Markers
- Mini-review: Fibroblast Growth Factors (FGFs)
- Receptor Tyrosine Kinases (RTKs)
- Receptor Tyrosine Kinases (RTKs) in the Akt Pathway
- Receptors in the Jak/STAT Pathway
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