CD314 (NKG2D)-VioBright FITC,r 200 tests
货号：
130-106-929 基本售价：
询价 规格：
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产品信息
概述| 货号 | 130-106-929 |
| 描述 | Clone REA471 recognizes the rat CD314 antigen, a single-pass type II membrane homodimeric glycoprotein belonging to the C-type lectin-like receptor family, which is also known as NKG2-D type II integral membrane protein (NKG2D) or killer cell lectin-like receptor subfamily K member 1 (Klrk1). Rat CD314 is expressed in NK cells, and is strongly expressed in resting CD8+ and CD4+ T cells, but not by thymocytes or other hemopoietic cells. It functions as an activating and costimulatory receptor involved in immunosurveillance upon binding to various cellular stress-inducible ligands displayed at the surface of autologous tumor cells and virus-infected cells. CD314 provides both, stimulatory and costimulatory innate immune responses on activated killer cells, leading to cytotoxic activity. It acts as a costimulatory receptor for T cell–receptor in CD8+ T cell–mediated adaptive immune responses by amplifying T cell–activation. Ligands of CD314 belong to various subfamilies of MHC class I–related glycoproteins. Additional information: Clone REA471 displays negligible binding to Fc receptors. |
| 别名 | Klrk1, Nkg2d, NKLLR, NKR-P2, NKR-P2, NKG2D |
| 克隆号 | REA471 |
| 同种亚型 | recombinant human IgG1 |
