CD49d-Biotin, rat, MRa4-1, 100 tests
货号：
130-111-482 基本售价：
询价 规格：
-
产品信息
概述| 货号 | 130-111-482 |
| 描述 | Clone MRα4-1 recognizes the mouse CD49d antigen, a 150 kDa integrin family member, also known as integrin α4 chain or VLA-4α chain. Integrins are cell-surface receptors, expressed as heterodimers essential in various processes mediating intercellular or cell-matrix interaction. CD49d associates non-covalently with the integrin ß or ß1 (CD29) forming the complex VLA-4, which is expressed on peripheral lymphocytes, thymocytes, eosinophils, basophils, mast cells, dendritic cells, and monocytes. VLA-4 plays a critical role in adhesion and migration of cells into tissues by binding to its ligand VCAM-1 (CD106). In T cells, on ligation of MAdCAM-1, α4β7 integrin also provides costimulation of T cell receptor/CD3–mediated signaling. |
| 别名 | ITGA4, α4 integrin chain, VLA-4α chain |
| 克隆号 | MRα4-1 |
| 同种亚型 | rat IgG2aκ |
