| 货号 | 23177S |
| 同种亚型 | Rabbit IgG |
| 反应种属 | H M R Mk |
| 来源宿主 | Rabbit IgG |
| 应用 | W |
| 目标/特异性 | OGT (D1D8Q) Rabbit mAb (HRP Conjugate) recognizes endogenous levels of total OGT protein. |
| 使用方法 | WB(1:1000) |
| 供应商 | CST |
| 灵敏度 | Endogenous |
| 背景 | O-GlcNAcylation is a post-translational modification where β-D-N-acetylglucosamine (GlcNAc) is covalently linked to cytoplasmic and nuclear proteins at serine or threonine residues (1,2). This modification is important in many cellular processes including metabolism, cell growth and morphogenesis, apoptosis, and transcription (2,3), and research studies have implicated this modification in cancer (1). The reversible protein modification by O-GlcNAc, which has been suggested to be a nutrient and stress sensor, is catalyzed by two highly conserved enzymes, O-GlcNAc transferase (OGT) and O-GlcNAcase (OGA) (4). |
| 运输条件 | 0.75 |
| 存放说明 | -20C |
| 计算分子量 | 110 |
| 参考文献 | 1 . Comer, F.I. et al. (2001) Anal Biochem 293, 169-77. 2 . Slawson, C. and Hart, G.W. (2011) Nat Rev Cancer 11, 678-84. 3 . Capotosti, F. et al. (2011) Cell 144, 376-88. 4 . Hart, G.W. et al. (2007) Nature 446, 1017-22. |
Western blot analysis of extracts from 293T and C6 cells using OGT (D1D8Q) Rabbit mAb (HRP Conjugate). |
