ORF1p (D3W9O) Rabbit mAb
货号：
88701S 基本售价：
3360.0 元 规格：
-
产品信息
概述| 货号 | 88701S |
| 同种亚型 | Rabbit IgG |
| 反应种属 | H |
| 来源宿主 | Rabbit IgG |
| 应用 | W |
| 目标/特异性 | ORF1p (D3W9O) Rabbit mAb recognizes endogenous levels of total ORF1p protein. |
| 使用方法 | WB(1:1000) |
性能| 供应商 | CST |
| 灵敏度 | Endogenous |
| 背景 | LINE-1, also known as L1, is a non-long terminal repeat (non-LTR) retrotransposon with hundreds of thousands of copies in the human genome (1, 2). Like all non-LTRs, L1 replicates by target-primed reverse transcription (TPRT) (3). The L1 retrotransposon encodes two proteins critical to this process: ORF1p and ORF2p. ORF2p contributes to endonuclease and reverse transcriptase activity, while ORF1p acts as a nucleic acid chaperone that binds RNA (4-8). Many types of cancers have been shown to have L1 insertions within tumor suppressor genes, disrupting their expression and contributing to tumorigenesis (9). |
| 运输条件 | 0.75 |
| 存放说明 | -20C |
| 计算分子量 | 42 |
| 参考文献 | 1 . Kazazian, H.H. and Moran, J.V. (1998) Nat Genet 19, 19-24.
2 . Malik, H.S. et al. (1999) Mol Biol Evol 16, 793-805.
3 . Wilhelm, M. and Wilhelm, F.X. (2001) Cell Mol Life Sci 58, 1246-62.
4 . Scott, A.F. et al. (1987) Genomics 1, 113-25.
5 . Moran, J.V. et al. (1996) Cell 87, 917-27.
6 . Feng, Q. et al. (1996) Cell 87, 905-16.
7 . Martin, S.L. and Bushman, F.D. (2001) Mol Cell Biol 21, 467-75.
8 . Kolosha, V.O. and Martin, S.L. (1997) Proc Natl Acad Sci U S A 94, 10155-60.
9 . Lee, E. et al. (2012) Science 337, 967-71.
10 . Rodić, N. et al. (2015) Nat Med 21, 1060-4.
11 . Doucet-OHare, T.T. et al. (2015) Proc Natl Acad Sci U S A 112, E4894-900.
12 . Chen, L. et al. (2012) Breast Cancer Res Treat 136, 129-42.
13 . Rodić, N. et al. (2014) Am J Pathol 184, 1280-6.
14 . Cook, P.R. et al. (2015) Proc Natl Acad Sci U S A 112, 4298-303.
|
参考图片Western blot analysis of extracts from various cell lines using ORF1p (D3W9O) Rabbit mAb (upper) and β-Actin (13E5) Rabbit mAb #4970 (lower). |
