| 货号 | 12697S |
| 反应种属 | Human/Mouse/Rat/Monkey |
| 来源宿主 | Rabbit |
| 应用 | W/IP |
| 使用方法 | WB(1:1000) IP (1:200) |
| 供应商 | CST |
| 背景 | Arrestin proteins function as negative regulators of G protein-coupled receptor (GPCR) signaling. Cognate ligand binding stimulates GPCR phosphorylation, which is followed by binding of arrestin to the phosphorylated GPCR and the eventual internalization of the receptor and desensitization of GPCR signaling (1). Four distinct mammalian arrestin proteins are known. Arrestin 1 (also known as S-arrestin) and arrestin 4 (X-arrestin) are localized to retinal rods and cones, respectively. Arrestin 2 (also known as β-arrestin 1) and arrestin 3 (β-arrestin 2) are ubiquitously expressed and bind to most GPCRs (2). β-arrestins function as adaptor and scaffold proteins and play important roles in other processes, such as recruiting c-Src family proteins to GPCRs in Erk activation pathways (3,4). β-arrestins are also involved in some receptor tyrosine kinase signaling pathways (5-8). Additional evidence suggests that β-arrestins translocate to the nucleus and help regulate transcription by binding transcriptional cofactors (9,10). |
| 存放说明 | -20C |
| 计算分子量 | 51 |
Western blot analysis of extracts from MDA-MB-435, Hep G2, and PANC-1 cells using β-Arrestin 1 (D8O3J) Rabbit mAb. | |
使用β-Arrestin 1 (D8O3J) Rabbit mAb兔单抗对MDA-MB-435, Hep G2, 和 PANC-1细胞提取物进行western blot分析。 | |
Western blot analysis of extracts from A549 cells, vehicle-treated (-) or treated with dexamethasone (100 nM, 24 h; +), using β-Arrestin 1 (D8O3J) Rabbit mAb (upper) and β-Actin (D6A8) Rabbit mAb #8457 (lower). |
