Bcr-Abl (b2a2 Junction Specific) (L99H4) Mouse mAb
货号：
3908S 基本售价：
3360.0 元 规格：
-
产品信息
概述| 货号 | 3908S |
| 反应种属 | Human |
| 来源宿主 | Mouse |
| 应用 | W |
| 使用方法 | WB(1:1000) |
性能| 供应商 | CST |
| 背景 | The Bcr gene was orginally identified by its presence in the chimeric Bcr-Abl oncogene (1). The amino-terminal region of Bcr contains an oligomerization domain, a serine/threonine kinase domain and a region that binds SH2 domains. The middle of the protein has a PH domain and a region of sequence similarity to the guanine nucleotide exchange factors for the Rho family of GTP binding proteins. The carboxy-terminal region may be involved in a GTPase activating function for the small GTP-binding protein Rac (2,3). The function of wild type Bcr in cells remains unclear. PDGF receptor may use Bcr as a downstream signaling mediator (4). The Bcr-Abl fusion results in production of a constitutively active tyrosine kinase, which causes chronic myelogenous leukemia (CML) (5). Tyr177 of Bcr is phosphorylated in the Bcr-Abl fusion protein, which plays an important role in transforming the activity of Bcr-Abl (6). Phosphorylated Tyr177 of Bcr provides a docking site for Gab2 and GRB2 (7,8). |
| 存放说明 | -20C |
| 计算分子量 | 210 |
参考图片Western blot analysis of various cell lysates from cell lines expressing Bcr-Abl fusion proteins, using Bcr-Abl (b2a2 Junction Specific) (L99H4) Mouse mAb (upper) and c-Abl Antibody #2862 (lower). western blot方法检测细胞提取物：表达Bcr-Abl (b2a2)融合蛋白的各种细胞裂解物，使用的抗体是Bcr-Abl (b2a2 Junction Specific) (L99H4) Mouse mAb (上图) 和 c-Abl Antibody #2862 (下图)。 |
