| 货号 | 12252S |
| 反应种属 | Human |
| 来源宿主 | Rabbit |
| 应用 | W/IP |
| 目标/特异性 | CPT1A (D3B3) Rabbit mAb recognizes endogenous levels of total CPT1A protein. |
| 使用方法 | WB(1:1000) IP (1:50) |
| 供应商 | CST |
| 背景 | Carnitine palmitoyltransferase-1 (CPT1), localized to the mitochondrial outer membrane, translocates fatty acids across the mitochondrial membranes and catalyzes the rate-limiting step of β-oxidation (1, 2). There are three isoforms of this enzyme: CPT1A (liver), CPT1B (muscle), and CPT1C (brain) (1, 2). Deficiency of CPT1A results in an autosomal recessive mitochondrial fatty acid oxidation disorder (3). Studies have shown that physiological high blood glucose and insulin levels inhibit CPT1B activity in human muscle and therefore divert long-chain fatty acids toward storage in human muscle as triglycerides (4). Furthermore, mice deficient in CPT1C show less food intake and reduced body weight (5). These findings suggest that CPT1 may play a role in metabolic syndromes. |
| 存放说明 | -20C |
| 计算分子量 | 88 |
Western blot analysis of extracts from HeLa, PANC-1, and MCF7 cells using CPT1A (D3B3) Rabbit mAb. Western blot 检测HeLa，PANC-1和MCF7 细胞系提取物，使用抗体为CPT1A (D3B3) Rabbit mAb兔单抗。 |
