DYRK2 (D9A3K) Rabbit mAb
货号：
11921S 基本售价：
3360.0 元 规格：
-
产品信息
概述| 货号 | 11921S |
| 反应种属 | Human/Mouse/Rat/Hamster/Monkey |
| 来源宿主 | Rabbit |
| 应用 | W |
| 使用方法 | WB(1:1000) |
性能| 供应商 | CST |
| 背景 | The DYRK family includes several dual-specificity tyrosine-phosphorylated and regulated kinases capable of phosphorylating proteins at both Tyr and Ser/Thr residues (1). The DYRK family was identified based on homology to the yeast Yak1 (2) and the Drosophila minibrain (mnb) kinases (3). Seven mammalian isoforms have been discovered, including DYRK1A, DYRK1B, DYRK1C, DYRK2, DYRK3, DYRK4, and DYRK4B. Differences in substrate specificity, expression, and subcellular localization are seen across the DYRK family (4,5). All DYRK proteins have a Tyr-X-Tyr motif in the catalytic domain activation loop; phosphorylation of the second Tyr residue (e.g. Tyr312 of DYRK1A) is necessary for kinase activity. DYRKs typically autophosphorylate the Tyr residue within their activation loop, but phosphorylate substrates at Ser and Thr residues (1,6).DYRK家族包括一些具有双重特异性的激酶，它们的酪氨酸被磷酸化并且能够磷酸化蛋白的酪氨酸和丝氨酸/苏氨酸残基（1）。DYRK家族是由于和酵母中的Yak1（2）蛋白和果蝇minibrain（mnb）激酶（3）同源而被发现的。在哺乳动物体内共发现了7中亚型，包括DYRK1A, DYRK1B, DYRK1C, DYRK2, DYRK3, DYRK4,和DYRK4B.DYRK家族的底物存在特异性，表达水平和细胞内位置的不同（4,5）。所有的DYRK蛋白的催化结构域都存在一个Tyr-X-Tyr基序；磷酸化第二个酪氨酸残基（例如DYRK1A的312位酪氨酸）可以激活激酶活性。DYRKs通常会在他们的激活区域自身磷酸化酪氨酸，但是磷酸化底物的丝氨酸和苏氨酸（1,6）。 |
| 存放说明 | -20C |
| 计算分子量 | 60, 66 |
参考图片Western blot analysis of extracts from various cell lines using DYRK2 (D9A3K) Rabbit mAb.使用DYRK2 (D9A3K)Rabbit mAb对多种细胞提取物进行western blot分析。 |
