| 货号 | 3829S |
| 反应种属 | Mouse/Rat |
| 来源宿主 | Rabbit |
| 应用 | W/IP/IHC-P |
| 目标/特异性 | FAAH1 (C84F1) Rabbit mAb detects endogenous levels of total FAAH1 protein. |
| 使用方法 | WB(1:1000) IP (1:50) IHC-P (1:3200) |
| 供应商 | CST |
| 背景 | Endogenous cannabinoids have been implicated in addictive behaviors and drug abuse (1). Fatty-acid amide hydrolase 1 (FAAH1) is a plasma membrane-bound hydrolase that converts oleamide to oleic acid (2). This hydrolase also converts the cannabinoid anandamide, the endogenous ligand for the CB1 cannabinoid receptor, to arachidonic acid, suggesting a role in fatty-acid amide inactivation (2). Mice lacking FAAH1 have significantly higher levels of anandamide in the brain and show decreased sensitivity to pain, further indicating a role for FAAH1 in the regulation of endocannabinoid signaling in vivo (3). FAAH1 null mice also demonstrate an increased preference for alcohol and an increased voluntary uptake of alcohol as compared to wild-type mice, indicating a role of FAAH1 in modulating addictive behaviors (1). |
| 存放说明 | -20C |
| 计算分子量 | 60 |
Western blot analysis of extracts from rat brain and INS-1 cells using FAAH1 (C84F1) Rabbit mAb. Wetern blot检测大鼠大脑和INS-1细胞提取物，所用抗体为FAAH1 (C84F1) Rabbit mAb兔单抗。 | |
Immunohistochemical analysis of paraffin-embedded rat cerebellum using FAAH1 (C84F1) Rabbit mAb. 免疫组织化学检测石蜡包埋的大鼠小脑组织，所用抗体为FAAH1 (C84F1) Rabbit mAb兔单抗 |
