| 货号 | 26865S |
| 同种亚型 | Rabbit IgG |
| 反应种属 | Human, Mouse, Rat, Monkey |
| 应用 | WB,IP |
| 目标/特异性 | OGDH (E1W8H) Rabbit mAb recognizes endogenous levels of total OGDH protein. |
| 使用方法 | Western Blotting (1:1000) Immunoprecipitation (1:50) |
| 供应商 | CST |
| 灵敏度 | Endogenous |
| 背景 | 2-oxoglutarate dehydrogenase (OGDH) is one of three enzymes in the α ketoglutarate dehydrogenase complex (OGDC) that is responsible for catalyzing a rate-regulating step of the tricarboxylic acid (Krebs) cycle. Together with dihydrolipoamide S-succinyltransferase (DLST) and dihydrolipoamide dehydrogenase (DLD), OGDH helps to convert 2-oxoglutarate to succinyl-CoA and CO2 within eukaryotic mitochondria (1). Regulation of this enzyme complex is important for mitochondrial energy metabolism within cells (2). Research studies indicate that OGDH activity within the mitochondrial matrix is regulated by multiple factors, including calcium, the adenine nucleotides ATP and ADP, and NADH (2). |
| 存放说明 | -20C |
| 计算分子量 | 110 |
| 参考文献 | 1 . Sun, R.C. and Denko, N.C. (2014) Cell Metab 19, 285-92. 2 . Armstrong, C.T. et al. (2014) Biochem J 459, 369-81. |
Western blot analysis of extracts from various cell lines using OGDH (E1W8H) Rabbit mAb. |
