| 货号 | 14364S |
| 反应种属 | Human/Mouse/Rat/Monkey |
| 来源宿主 | Rabbit |
| 应用 | W/IP/IF-IC |
| 使用方法 | WB(1:1000) IP (1:50) IF-IC (1:400) |
| 供应商 | CST |
| 背景 | Insulin-like growth factor II (IGF-II) receptor, also widely known as cation-independent mannose 6-phosphate receptor (CI-M6PR), is a multifunctional type I transmembrane glycoprotein that participates in the internalization of mannose-6-phosphate modified hydrolases and IGF-II from the plasma membrane (1,2). In the absence of ligands, IGF-II receptor is constitutively endocytosed from the cell surface to accumulate in the Golgi apparatus (3). In the presence of ligands, the receptor transports the mannose-6-phosphate modified hydrolases to acidified endosomes and lysosomes (4). The ligand-free receptor is then transported back to the Golgi compartment or the cell surface (4). In several research studies, IGF-II receptor has been recognized as a tumor suppressor in a number of cancers (5-7). |
| 存放说明 | -20C |
| 计算分子量 | 275 |
Confocal immunofluorescent analysis of A172 (left, high expressing) and A549 (right, lower expressing) cells using IGF-II Receptor/CI-M6PR (D3V8C) Rabbit mAb (green). Blue pseudocolor = Propidium Iodide (PI)/RNase Staining Solution #4087. | |
Immunoprecipitation of IGF-II Receptor/CI-M6PR from HeLa cell extracts using Rabbit (DA1E) mAb IgG XP® Isotype Control #3900 (lane 2) or IGF-II Receptor/CI-M6PR (D3V8C) Rabbit mAb (lane 3). Lane 1 is 10% input. Western blot analysis was performed using IGF-II Receptor/CI-M6PR (D3V8C) Rabbit mAb. | |
Western blot analysis of extracts from various cells using IGF-II Receptor/CI-M6PR (D3V8C) Rabbit mAb. |
