JNK3 (55A8) Rabbit mAb
货号：
2305S 基本售价：
3360.0 元 规格：
-
产品信息
概述| 货号 | 2305S |
| 反应种属 | Human/Mouse/Rat |
| 来源宿主 | Rabbit |
| 应用 | W |
| 使用方法 | WB(1:1000) |
性能| 供应商 | CST |
| 背景 | The stress-activated protein kinase/Jun-amino-terminal kinase SAPK/JNK is potently and preferentially activated by a variety of environmental stresses including UV and gamma radiation, ceramides, inflammatory cytokines, and in some instances, by growth factors and GPCR agonists (1-6). As with the other MAPKs, the core signaling unit is composed of a MAPKKK, typically MEKK1-MEKK4, or by one of the mixed lineage kinases (MLKs), which phosphorylate and activate MKK4/7. Upon activation, MKKs phosphorylate and activate the SAPK/JNK kinase (2). Stress signals are delivered to this cascade by small GTPases of the Rho family (Rac, Rho, cdc42) (3). Both Rac1 and cdc42 mediate the stimulation of MEKKs and MLKs (3). Alternatively, MKK4/7 can be activated in a GTPase-independent mechanism via stimulation of a germinal center kinase (GCK) family member (4). There are three SAPK/JNK genes each of which undergoes alternative splicing resulting in numerous isoforms (3). SAPK/JNK, when active as a dimer, can translocate to the nucleus and regulate transcription through its effects on c-Jun, ATF-2, and other transcription factors (3,5). |
| 存放说明 | -20C |
| 计算分子量 | 54 |
参考图片Western blot analysis of extracts from human cerebellum, mouse brain and rat brain, using JNK3 (55A8) Rabbit mAb.Western blot检测人小脑 、小鼠和大鼠脑部提取物，使用的抗体是JNK3 (55A8) Rabbit mAb。 |
Western blot analysis of recombinant His-tagged JNK kinases (left), or brain lysates from wild type (WT) and specific JNK knockout (-/-) mice (right), using JNK3 (55A8) Rabbit mAb (Image provided by Drs Gerardo Morfini, YiMei You and Scott Brady, University of Illinois at Chicago).Western blot检测重组His-标记的JNK激酶（左侧）、野生型（WT）特异性JNK敲除 (-/-) 小鼠脑部裂解物（右侧），使用的抗体是JNK3 (55A8) Rabbit mAb （图像由芝加哥Illinois大学的Drs Gerardo Morfini, YiMei You 和Scott Brady提供，）。 |
