| 货号 | 12671S |
| 反应种属 | Human/Mouse/Rat/Monkey |
| 来源宿主 | Rabbit |
| 应用 | W/IHC-P |
| 使用方法 | WB(1:1000) IHC-P (1:250) |
| 供应商 | CST |
| 背景 | MEK1 and MEK2, also called MAPK or Erk kinases, are dual-specificity protein kinases that function in a mitogen activated protein kinase cascade controlling cell growth and differentiation (1-3). Activation of MEK1 and MEK2 occurs through phosphorylation of two serine residues at positions 217 and 221, located in the activation loop of subdomain VIII, by Raf-like molecules. MEK1/2 is activated by a wide variety of growth factors and cytokines and also by membrane depolarization and calcium influx (1-4). Constitutively active forms of MEK1/2 are sufficient for the transformation of NIH/3T3 cells or the differentiation of PC-12 cells (4). MEK activates p44 and p42 MAP kinase by phosphorylating both threonine and tyrosine residues at sites located within the activation loop of kinase subdomain VIII. |
| 存放说明 | -20C |
| 计算分子量 | 45 |
Immunohistochemical analysis of paraffin-embedded colon adenocarcinoma using MEK1 (D2R1O) Rabbit mAb in the presence of control peptide (left) or antigen-specific peptide (right). | |
在对照肽(左)或抗原特异性肽段(右)存在的条件下，使用MEK1 (D2R1O) Rabbit mAb兔单抗对石蜡包埋的人结肠癌组织进行免疫组化分析。 | |
Immunohistochemical analysis of paraffin-embedded cell pellets, wild type MEF (left), MEK1 (-/-) MEF (middle) or MEK2 (-/-) MEF (right), using MEK1 (D2R1O) Rabbit mAb. Cells provided by Dr. Jean Charron, Centre de recherche du Centre hospitalier de l’Université Laval, Quebec, Canada. |
