NLRC4 (D5Y8E) Rabbit mAb【科瑞奥博】

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NLRC4 (D5Y8E) Rabbit mAb

货号： 12421S 基本售价： 3360.0 元规格： -

产品信息

概述
货号	12421S
反应种属	Human
来源宿主	Rabbit
应用	W/IP
目标/特异性	NLRC4 (D5Y8E) Rabbit mAb recognizes endogenous levels of total NLRC4 protein.
使用方法	WB(1:1000) IP (1:100)

性能
供应商	CST
背景	The nucleotide-binding oligomerization domain (NOD)-like receptor (NLR) family of proteins is a diverse family of cytoplasmic innate immune receptors. They are characterized by the presence of an amino-terminal effector domain, which is often either a caspase activation and recruitment domain (CARD) or a pyrin domain (PYD), followed by a NOD and carboxy-terminal leucine-rich-repeat (LRR) domain involved in recognition of pathogen-associated molecular patterns (PAMPs) (1). NLR proteins play a variety of roles during the innate immune response including pathogen sensing, transcriptional activation of proinflammatory cytokines through NF-κB, transcriptional activation of type I interferons through IRFs, and formation of inflammasomes leading to activation of inflammatory caspases (1-7).核苷酸结合寡聚化结构域（NOD）样受体（NLR）蛋白家族是一种多样的细胞质先天性免疫受体家族，以一个氨基端效应者结构域为特征，常常是一个半胱天冬酶活化和募集结构域（CARD）或者一个pyrin结构域（PYD），后面有一个能识别病原体相关分子模式（PAMPs）的NOD和羧基端富含亮氨酸的重复单位（LRR）结构域（1）。NLR蛋白在先天性免疫应答过程中发挥多种作用，包括病原体传感、促炎细胞因子的转录激活（通过NF-κB）、I型干扰素的转录激活（通过IRFs）以及抗菌防卫体系的形成（引起炎性半胱氨酸天冬氨酸蛋白酶的激活）（1-7）。
存放说明	-20C
计算分子量	110

参考图片

Western blot analysis of extracts from THP-1 and MUTZ-3 cells using NLRC4 (D5Y8E) Rabbit mAb. Western blot分析THP-1和MUTZ-3细胞的提取物，使用的抗体是：NLRC4 (D5Y8E) Rabbit mAb。

Western blot analysis of extracts from 293T cells, mock transfected (-) or transfected with a construct expressing full-length human NLRC4 (hNLRC4; +), using NLRC4 (D5Y8E) Rabbit mAb.Western blot分析293T细胞提取物，对照转染(-)或用全长的人NLRC4 (hNLRC4; +)转染，使用的抗体是：NLRC4 (D5Y8E) Rabbit mAb。

Immunoprecipitation of NLRC4 from MUTZ-3 cell extracts using Rabbit (DA1E) mAb IgG XP® Isotype Control #3900 (lane 2) or NLRC4 (D5Y8E) Rabbit mAb (lane 3). Lane 1 is 10% input. Western blot analysis was performed using NLRC4 (D5Y8E) Rabbit mAb.免疫沉淀分析来源于MUTZ-3细胞提取物的NLRC4，使用的抗体是：Rabbit (DA1E) mAb IgG XP® Isotype Control #3900（泳道2）、NLRC4 (D5Y8E) Rabbit mAb（泳道3）。泳道1是10% input。Western blot分析使用的抗体是NLRC4 (D5Y8E) Rabbit mAb。