| 货号 | 40134S |
| 同种亚型 | Rabbit IgG |
| 反应种属 | Human |
| 来源宿主 | Rabbit IgG |
| 应用 | IHC-P |
| 目标/特异性 | DPP4 (D6D8K) Rabbit mAb recognizes endogenous levels of total DPP4 protein. |
| 使用方法 | IHC-P(1:200) |
| 供应商 | CST |
| 灵敏度 | Endogenous |
| 背景 | DPP4 (CD26) is a type II transmembrane glycoprotein expressed ubiquitously in most tissues and different cell types (1,2). The protein has a short cytoplasmic domain, transmembrane domain, a flexible stalk fragment and extracellular fragment (2). Both the catalytic peptide hydrolase domain and the beta-propeller ligand binding domain are located in the extracellular fragment (2). DPP4 is a multifunctional protein that exists in both a membrane bound form as well as an extracellular soluble form. As a peptidase, it removes N-terminal dipeptides sequentially from proteins with a proline or alanine as the penultimate P1 amino acid (3.4). DPP4 has been shown to cleave a wide range of substrates including GLP-1, BNP, substance P, etc. It is also involved in the regulation of related biological functions (5). In addition to it peptidase activity, DPP4 interacts with multiple important cell surface ligands, such as adenosine deaminase, fibronectin, and IGF2 receptor to influence processes like T cell activation, cell migration and proliferation (5). Several DPP4 inhibitors have been developed and their effects have been tested in the field of diabetes, cardiovascular disease and tumor immunity (2,5,6). |
| 存放说明 | -20C |
| 参考文献 | 1 . Mentzel, S. et al. (1996) J Histochem Cytochem 44, 445-61. 2 . Röhrborn, D. et al. (2015) Front Immunol 6, 386. 3 . Hopsu-Havu, V.K. and Glenner, G.G. (1966) Histochemie 7, 197-201. 4 . Lone, A.M. et al. (2010) AAPS J 12, 483-91. 5 . Zhong, J. et al. (2015) J Diabetes Res 2015, 606031. 6 . Ohnuma, K. et al. (2015) Nat Immunol 16, 791-2. |
Immunohistochemical analysis of paraffin-embedded Caco-2 (left) and HT-1080 (right) cell pellets using DPP4/CD26 (D6D8K) Rabbit mAb. | |
Immunohistochemical analysis of paraffin-embedded normal human kidney using DPP4/CD26 (D6D8K) Rabbit mAb. | |
Immunohistochemical analysis of paraffin-embedded human colon carcinoma using DPP4/CD26 (D6D8K) Rabbit mAb in the presence of control peptide (left) or antigen-specific peptide (right). | |
Immunohistochemical analysis of paraffin-embedded human prostate carcinoma using DPP4/CD26 (D6D8K) Rabbit mAb. |
