| 货号 | 3728S |
| 反应种属 | Mouse |
| 来源宿主 | Rabbit |
| 应用 | W/IHC-P |
| 目标/特异性 | Sox2 (C70B1) Rabbit mAb (IHC Preferred) detects endogenous levels of Sox2 protein. |
| 使用方法 | WB(1:1000) IHC-P (1:250) |
| 供应商 | CST |
| 背景 | Embryonic stem cells are derived from the inner cell mass of the blastocyst and are unique in their pluripotent capacity and potential for self-renewal. Sox2 is one of a set of transcription factors that are crucial for the maintenance of pluripotency (1). Sox2, Oct-4, and Nanog cooperate in this network (1-3) and siRNA knockdown of either Sox2 or Oct-4 results in loss of pluripotency (4,5). Chromatin immunoprecipitation experiments have shown that Sox2 and Oct-4 bind to thousands of gene regulatory sites, highlighting the importance of these transcription factors in early embryonic development (6,7). It has recently been shown that Sox2 is amplified in lung and esophageal squamous cell tumors (8). |
| 存放说明 | -20C |
| 计算分子量 | 35 |
Immunohistochemical analysis of paraffin-embedded 14.5 day mouse embryo using Sox2 (C70B1) Rabbit mAb (IHC Preferred). Note staining of ventricular/subventricular zone.使用Sox2 (C70B1) 兔单抗（IHC首选）对石蜡包埋的14.5天小鼠胚胎进行免疫组化分析。注意心室和室下区域染色部位。 | |
Immunohistochemical analysis of paraffin-embedded F9 cells (positive, left) and C2C12 cells (negative, right) using Sox2 (C70B1) Rabbit mAb (IHC Preferred).使用Sox2 (C70B1)兔单抗（IHC首选对石蜡包埋的F9细胞（阳性，左）和C2C12细胞（阴性，右）进行免疫组化分析。 | |
Western blot analysis of extracts from mouse embryonic stem cells (mESCs) and F9 cells using Sox2 (C70B1) Rabbit mAb (IHC Preferred).使用Sox2 (C70B1)兔单抗（IHC首选）对小鼠胚胎干细胞（mESCs）和F9细胞提取物进行western blot分析。 |
