| 货号 | 13801S |
| 反应种属 | Human/Mouse/Rat |
| 来源宿主 | Rabbit |
| 应用 | W/IHC-P |
| 使用方法 | WB(1:1000) IHC-P (1:1000) |
| 供应商 | CST |
| 背景 | The Thy1 cell surface antigen is a GPI-anchored, developmentally regulated protein involved in signaling cascades that mediate neurite outgrowth, T cell activation, tumor suppression, apoptosis, and fibrosis (1). Thy1 is highly expressed on the surface of adult neurons and is thought to play a role in modulating adhesive and migratory events, such as neurite extension (1,2). Decreased Thy1 mRNA and protein expression is associated with the development of epithelial ovarian cancer, suggesting a role as a putative tumor suppressor gene of human ovarian cancer (3,4). Research studies indicate that Thy1 knockout mice have impaired cutaneous immune responses and abnormal retinal development (5,6). Thy1 is epigenetically regulated or deregulated in some disease states, such as pulmonary fibrosis. The potentially reversible hypermethylation of the Thy1 promoter offers the possibility of novel therapeutic options in this disease (7). |
| 存放说明 | -20C |
| 计算分子量 | 22 |
Immunohistochemical analysis of paraffin-embedded human colon adenocarcinoma using Thy1 (D3V8A) Rabbit mAb in the presence of control peptide (left) or antigen-specific peptide (right). | |
Immunohistochemical analysis of paraffin-embedded human lung carcinoma using Thy1 (D3V8A) Rabbit mAb. | |
Immunohistochemical analysis of paraffin-embedded human brain using Thy1 (D3V8A) Rabbit mAb. | |
Western blot analysis of extracts from mouse, rat, and human brain using Thy1 (D3V8A) Rabbit mAb (upper) and GAPDH (D16H11) XP® Rabbit mAb #5174 (lower). | |
Immunohistochemical analysis of paraffin-embedded mouse spleen using Thy1 (D3V8A) Rabbit mAb. |
