| 货号 | 15140S |
| 反应种属 | Human/Mouse/Rat/Hamster/Monkey |
| 来源宿主 | Rabbit |
| 应用 | W/IHC-P |
| 使用方法 | WB(1:1000) IHC-P (1:100) |
| 供应商 | CST |
| 背景 | TRXR1 (thioredoxin reductase 1) is a selenocysteine-containing protein that is involved in redox homeostasis (1-6). Its canonical target is thioredoxin, another redox protein (1). Together, they are involved in many functions such as antioxidant regulation (3-6), cell proliferation (2,3,5), DNA replication (2,3), and transcription (3,5). TRXR1 is also capable of reducing a wide array of cellular proteins (1,3). Selenium deficiency, either by diet modification (2,6) or introduction of methylmercury (4), hinders proper expression and function of TRXR1. It is possible that this effect, which results in a higher oxidative state, is a result of the selenocysteine codon (UGA) being read as a STOP codon in the absence of adequate selenium (4). The functions of TRXR1 in cell proliferation and antioxidant defense make it a potential therapeutic target. |
| 存放说明 | -20C |
| 计算分子量 | 55 |
Western blot analysis of Caco-2 cells, untreated (-) or treated (+) for 48 hr with R-sulforaphane (SFN; 10 μM) and sodium selenite (100 nM), using TRXR1 (D1T3D) Rabbit mAb (upper) and GAPDH (D16H11) XP® Rabbit mAb #5174 (lower). | |
Western blot analysis of extracts from various cell lines and tissues using TRXR1 (D1T3D) Rabbit mAb. | |
Immunohistochemical analysis of paraffin-embedded human testis using TRXR1 (D1T3D) Rabbit mAb. | |
Immunohistochemical analysis of paraffin-embedded Caco-2 cells, untreated (left) and R-sulforaphane (SFN) and sodium selenite-treated (right), using TRXR1 (D1T3D) Rabbit mAb. | |
Immunohistochemical analysis of paraffin-embedded human prostate carcinoma using TRXR1 (D1T3D) Rabbit mAb. | |
Immunohistochemical analysis of paraffin-embedded human ovarian carcinoma using TRXR1 (D1T3D) Rabbit mAb. | |
Immunohistochemical analysis of paraffin-embedded human lung carcinoma using TRXR1 (D1T3D) Rabbit mAb. |
