| 货号 | 13141T |
| 同种亚型 | Rabbit IgG |
| 反应种属 | Human/Mouse/Rat/Monkey |
| 来源宿主 | Rabbit |
| 应用 | W/IHC-P |
| 目标/特异性 | SOD2 (D3X8F) XP® Rabbit mAb recognizes endogenous levels of total SOD2 protein. |
| 使用方法 | WB(1:1000) IHC-P (1:1000) |
| 供应商 | CST |
| 灵敏度 | Endogenous |
| 背景 | Manganese superoxide dismutase (MnSOD or SOD2) is a mitochondrial detoxification enzyme that catalyzes the conversion of superoxide to hydrogen peroxide (1,2). Hydrogen peroxide is then decomposed to water by catalase, glutathione peroxidase, or peroxiredoxins (2). MnSOD/SOD2 and other enzymes involved in antioxidant defense protect cells from reactive oxygen species (ROS) (2). Calorie restriction leads to SIRT3-mediated deacetylation of MnSOD/SOD2 and the subsequent increase of its antioxidant activity (3). MnSOD/SOD2 also plays an essential role in mediating the protective effect of mTOR inhibition to reduce epithelial stem cell senescence (4). |
| 存放说明 | -20C |
| 计算分子量 | 22 |
| 参考文献 | 1 . Cooper, M.L. et al. (2008) Cancer Res 68, 10171-7. 2 . Minig, V. et al. (2009) J Biol Chem 284, 14165-76. 3 . Qiu, X. et al. (2010) Cell Metab 12, 662-7. 4 . Iglesias-Bartolome, R. et al. (2012) Cell Stem Cell 11, 401-14. |
Immunohistochemical analysis of paraffin-embedded human kidney using SOD2 (D3X8F) XP® Rabbit mAb in the presence of control peptide (left) or antigen-specific peptide (right). 在对照肽(左)或抗原特异性肽段(右)存在的情况下，使用SOD2 (D3X8F) XP® Rabbit mAb兔单抗对石蜡包埋的人肾脏组织进行免疫组化分析。 | |
Immunohistochemical analysis of paraffin-embedded human colon adenocarcinoma using SOD2 (D3X8F) XP® Rabbit mAb. 使用SOD2 (D3X8F) XP® Rabbit mAb兔单抗对石蜡包埋的人结肠癌组织进行免疫组化分析。 | |
Immunohistochemical analysis of paraffin-embedded normal mouse brain using SOD2 (D3X8F) XP® Rabbit mAb. 使用SOD2 (D3X8F) XP® Rabbit mAb兔单抗对石蜡包埋的正常小鼠脑组织进行免疫组化分析。 | |
Western blot analysis of extracts from various cell lines using SOD2 (D3X8F) XP® Rabbit mAb. 使用SOD2 (D3X8F) XP® Rabbit mAb兔单抗对多种细胞提取物进行western blot分析。 |
