CD104 Pure 7/CD104 150ug
货号：
611233 基本售价：
7885.0 元 规格：
-
产品信息
概述| 货号 | 611233 |
| 描述 | Cell adhesion to extracellular matrix components or to cell surface proteins, especially those expressed by leukocytes and endothelial cells, is mediated by integrins. Integrins contain noncovalently associated αandβ subunits. At least 17 α and 8 β subunits have been identified and these proteins can heterodimerize to form 22 different receptors. The α6β 4 integrin is a receptor for various laminins and binds with the highest affinity to laminins 4 and 5. It exhibits elevated expression in the basal cell layer of stratified epithelia, in Schwann cells at the onset of myelination, and in CD4-CD8- pre-T lymphocytes entering the thymus. In addition, α6β 4 expression is increased in squamous carcinomas where it promotes invasion through a targeting of PI3 kinase activity. The majority of β 4 comprises a cytoplasmic domain with unique signaling properties. The C-terminal portion of this domain contains two pairs of type III fibronectin-like motifs (FNIII) and a tyrosine activation motif (TAM). Additional domains in the cytoplasmic tail bind Shc and activate the MAPK pathway. Thus, integrin β 4 is an integrin subunit that is important for cell survival, growth, and differentiation. |
| 别名 | Integrin β4 |
| 同种亚型 | IgG1 |
| 反应种属 | Human (QC Testing) |
| 来源宿主 | Mouse |
| 使用方法 | WB, IF |
性能| 供应商 | BD Pharmingen |
| 免疫原 | Human Integrin β4 aa. 1612-1821 |
| 存放说明 | The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.Store undiluted at -20°C.
|
| 存储溶液 | Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide. |
| 浓度 | 250 µg/ml |
