Rat CD8B NALE 341 500ug
货号：
562210 基本售价：
6820.0 元 规格：
-
产品信息
概述| 货号 | 562210 |
| 描述 | The 341 antibody reacts with the β chain of the CD8 antigen on most thymocytes and a subpopulation of mature T lymphocytes (ie, MHC class I-restricted T cells, including most T suppressor/cytotoxic cells). The CD8 αandβ chains (CD8a and CD8b, respectively) form a heterodimer on the surface of most thymocytes and thymus-dependent T suppressor/cytotoxic cells, whereas intestinal intraepithelial lymphocytes, many CD8+ T cells of athymic rats, many activated CD4+ T cells, and most NK cells express CD8a without CD8b. It has been suggested that the expression of the CD8a/CD8b heterodimer is restricted to thymus-derived T lymphocytes. CD8 is an antigen co-receptor on the T cell surface which interacts with MHC class I molecules on antigen-presenting cells. It participates in T-cell activation through its association with the T-cell receptor complex and protein tyrosine kinase lck. Macrophages have also been reported to express CD8 αandβ chains, which are involved in signal transduction. The 341 mAb blocks proliferative and cytotoxic in vitro responses of CD8+ effectors to allogeneic cells. |
| 别名 | Cd8b; CD8beta; CD8 beta; CD8-beta; CD8β |
| 同种亚型 | Mouse BALB/c IgG1, κ |
| 反应种属 | Rat (QC Testing) |
性能| 供应商 | BD Pharmingen |
| 免疫原 | CD8-positive Wistar rat splenic T-cell hybridomas |
| 标记 | NA/LE |
| 存放说明 | Store undiluted at 4°C.The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.This preparation contains no preservatives, thus it should be handled under aseptic conditions.
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| 存储溶液 | No azide/low endotoxin: Aqueous buffered solution containing no preservative, 0.2µm sterile filtered. Endotoxin level is ≤0.01 EU/µg (≤0.001 ng/µg) of protein as determined by the LAL assay. |
| 浓度 | 1.0 mg/ml |
