APAF-1 Pure Poly 50ug
货号：
559683 基本售价：
6210.0 元 规格：
-
产品信息
概述| 货号 | 559683 |
| 描述 | Apoptosis can be induced by a family of cell death receptors (tumor necrosis factor) and their respective ligands. Cell death signals are transduced by death domain containing adapter molecules and members of the caspase family of proteases. Another mechanism of inducing apoptosis involves the participation of the mitochrondria in which various forms of cellular stress can trigger the release of cytochrome c from the intermembrane space (IMS) of the mitochrondria into the cytoplasm. The mammalian homologue of the CED-4 cell death gene in C. elegans has been identified from human and mouse and designated APAF-1 (for Apoptosis Protease Activating Factor-1). Cytochrome c associates with APAF-1 in the presence of dATP or ATP and induces an oligomerization of APAF-1 which then binds procaspase-9, forming an “apoptosome” containing APAF-1, cytochrome c and procaspase-9. Recent studies have shown that dATP/ATP hydrolysis is necessary for APAF-1 to interact with cytochrome c and bind to procaspase-9. Procaspase-9 is then processed via an intrinsic autocatalytic activity of itself, triggered by APAF-1, which now allows caspase-9 to activate the downstream executioners caspase-3, -6 and -7. This antibody has been reported to recognize both human and mouse APAF-1. A peptide corresponding to amino acids 12 to 28 of human APAF-1 was used as the immunogen where the sequence of this peptide have been reported to be identical between both human and mouse. |
| 别名 | Apoptosis Protease Activating Factor-1 |
| 同种亚型 | Ig |
| 反应种属 | Human (QC Testing) Mouse (Reported) |
| 来源宿主 | Rabbit |
| 使用方法 | WB |
性能| 供应商 | BD Pharmingen |
| 存放说明 | The polyclonal antibody was purified from antiserum by affinity chromatography.Store undiluted at 4°C.
|
| 存储溶液 | Aqueous buffered solution containing ≤0.09% sodium azide. |
| 浓度 | 0.5 mg/ml |
