Ms CD127 NALE SB/14 500ug
货号：
550426 基本售价：
4592.0 元 规格：
-
产品信息
概述| 货号 | 550426 |
| 描述 | The SB/14 monoclonal antibody specifically binds to mouse CD127 which is also known as, the Interleukin-7 Receptor alpha chain ( IL-7Rα ). CD127 associates with CD132 ( common γ chain ) to form a high-affinity signaling IL-7R complex that mediates the biological effects of IL-7. CD127 can also complex with the Thymic Stromal Lymphopoietin Receptor (TSLPR) subunit to bind and mediate cellular responses to TSLP. CD127 is a 65-75 kDa type-I transmembrane protein that belongs to the hematopoietin receptor and the Ig gene superfamilies. Mice lacking CD127 display profoundly impaired development of the B and T lymphoid cell lineages, but display no obvious non lymphoid abnormalities. IL-7Rα is expressed on common lymphoi d progenitors and early stages of B lineage development in the bone marrow, on the earliest thymocyte progenitors, on CD4-CD8- double-negative and CD4+ and CD8+ single-positive thymocytes, and on most peripheral T lymphocytes. Intestinal intraepithelial lymphocytes with low-density γδ TCR expression upregulate CD127 expression in response to IL-2, which may be secreted by ne ighboring αβ TCR+ T cells. The SB/14 mAb neutralizes IL-7-induced proliferation of the IL-7-dependent immature B-lymphocyte line 2E8 (detected by BrdU incorporation). |
| 别名 | Interleukin-7 receptor alpha chain; IL-7R alpha; IL7RA;IL-7RA; IL-7Rα; Il7r |
| 同种亚型 | IgG2a,κ |
| 反应种属 | Mouse (QC Testing) |
| 来源宿主 | Rat |
| 使用方法 | FC |
性能| 供应商 | BD Pharmingen |
| 免疫原 | BALB/c mouse pre-B cell line 1A9 |
| 标记 | NA/LE |
| 存放说明 | Store undiluted at 4°C.The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.This preparation contains no preservatives, thus it should be handled under aseptic conditions.
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| 存储溶液 | No azide/low endotoxin: Aqueous buffered solution containing no preservative, 0.2µm sterile filtered. Endotoxin level is ≤0.01 EU/µg (≤0.001 ng/µg) of protein as determined by the LAL assay. |
| 浓度 | 1.0 mg/ml |
