cGB-PDE Pure 54/cGB-PDE 50ug
货号：
611498 基本售价：
4305.0 元 规格：
-
产品信息
概述| 货号 | 611498 |
| 描述 | cGMP is involved in nitric oxide signaling, as well as cell signaling associated with natriuretic peptides and guanylins. Intracellular targets for cGMP include cGMP-dependent protein kinase, cyclic nucleotide-gate ion channels, and cGMP-Binding PhosphoDiesterases (cGB-PDE). Tissue levels of cGMP are determined by guanylyl cyclases that catalyze the formation of cGMP and cyclic nucleotide PDEs that catalyze the breakdown of cGMP. In the PDE superfamily PDE2, PDE5, PDE6, and PDE10 have dimeric structures that contain highly cGMP-specific allosteric cGMP binding sites in addition to a phosphodiesterase catalytic site. PDE5 is highly expressed in aorta and lung, but is also expressed in intestine, kidney, adrenal gland, cerebellum, and cerebrum. In the cerebellum, PDE5 is expressed in the Purkinje cell layer during neonatal development. PDE5 is also abundant in vascular smooth muscle cells where it is involved in regulating cGMP levels and vascular smooth muscle tonicity. Thus, PDE5 is important for regulating cGMP levels in both neuronal and non-neuronal tissues that utilize cGMP signaling pathways for the regulation of cell function. |
| 别名 | PDE5; cGMP-Binding PhosphoDiesterases |
| 同种亚型 | IgG1 |
| 反应种属 | Rat (QC Testing) |
| 来源宿主 | Mouse |
| 使用方法 | WB |
性能| 供应商 | BD Pharmingen |
| 免疫原 | Rat cGB-PDE aa. 2-108 |
| 存放说明 | The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.Store undiluted at -20°C.
|
| 存储溶液 | Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide. |
| 浓度 | 250 µg/ml |
