Bak Serum Poly 1030 0.1mL
货号：
556396 基本售价：
4218.0 元 规格：
-
产品信息
概述| 货号 | 556396 |
| 描述 | Bak (for Bcl-2 homologous Antagonist/Killer) is a recently identified member of the Bcl-2 family. Bcl-2 family members are involved in mediating programmed cell death or apoptosis, and share two highly conserved functional regions, Bcl-2 homology 1 and 2 (BH1 and BH2). Several of the family members including Bcl-2 act as inhibitors of apoptosis, whereas others such as Bax promote cell death. Like Bax, Bak primarily promotes apoptosis. However, unlike Bax, Bak has also been shown to inhibit cell death. For example, expression of Bak in a human lymphoblastoid cell line protected it from apoptosis induced by serum deprivation and menadione oxidation. It is thus thought that the function of Bak may be context dependent. Bak mRNA has been identified in a wide variety of fetal and adult tissues, with the highest levels observed in heart and skeletal muscle. The apparently ubiquitous expression of Bak has lead to the suggestion that its function may be mediated by cell death inhibitory factors, particularly in cell types with a long life span. This polyclonal antibody has been reported not to cross-react with other members of the Bcl-2 family, including Bcl-2, Bcl-XL, Bcl-XS, Bax, and Mcl-1. |
| 同种亚型 | Rabbit Ig |
| 来源宿主 | Rabbit |
| 使用方法 | WB, IHC(P) |
性能| 供应商 | BD Pharmingen |
| 免疫原 | Human Bak aa. 14-36 Peptide |
| 存储溶液 | Aqueous buffered solution containing ≤0.09% sodium azide and ≤0.03% thimerosal |
