Bta PIX Pure 23/Bta PIX 50ug
货号：
611648 基本售价：
4140.0 元 规格：
-
产品信息
概述| 货号 | 611648 |
| 描述 | The activity of PAK family kinases is regulated through interaction with the small GTPases Cdc42 and Rac1. PAKs are activated by the GTP-bound form of Cdc-42 and Rac1, and recruitment of PAKs to focal complexes has been implicated in Cdc42- and Rac1-dependent regulation of focal contact formation. PAK-i nteracting e x change factor (PIX) was identified in a screen for proteins that bind PAKs. Two forms of PIX have been identified: an 85 kDa protein designated α PIX and a 78 kDa protein designated β PIX. These proteins have 80% identity in their overlapping regions, which include myosin-like, pleckstrin (PH), Dbl (DH), and SH3 domains. In addition, α PIX contains a calponin-like domain at the N-terminus. The expression of β PIX is ubiquitous, while α PIX is expressed in heart, muscle, and thymus. PIX can act as a guanine nuleotide exchange factor for Rac1 and co-transfection of β PIX, Cdc42, and α PAK results in increased α PAK activity. PIX binding to PAK is required for localization of PAKs to focal complexes and injection of β PIX leads to Rac1-dependent membrane ruffling. Thus, PIX is important for PAK localization and activity during small GTPase-dependent regulation of cell morphology. |
| 同种亚型 | IgG1 |
| 反应种属 | Rat (QC Testing) Mouse, Dog, Chicken (Tested in Development) |
| 来源宿主 | Mouse |
| 使用方法 | WB, IF |
性能| 供应商 | BD Pharmingen |
| 免疫原 | Rat βPIX aa. 351-453 |
| 存放说明 | Store undiluted at -20°C.The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
|
| 存储溶液 | Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide. |
| 浓度 | 250 µg/ml |
