AKAP-KL Pure 41/AKAP-KL 50ug
货号：
611134 基本售价：
4140.0 元 规格：
-
产品信息
概述| 货号 | 611134 |
| 描述 | Cyclic AMP (cAMP) is a common second messenger for a variety of cytokines, hormones, and neurotransmitters. Central to this signaling pathway is the activation of cAMP-dependent protein kinase A (PKA). The non-uniform intracellular distribution of PKA isoforms allows for the delivery of cAMP-transmitted signals to discrete subcellular sites. This is mediated by the attachment of PKA isoforms to the cytoskeleton or organelles by AKAPs. AKAPs simultaneously bind to the RII subunits of PKAII and to the cytoskeleton. At least six AKAP-KL (Akinaseanchorproteins expressed in lung and kidney) proteins are generated by alternative mRNA splicing. They are present primarily in lung, kidney, and cerebellum and are absent from many other tissues. All isoforms consists of a 20-residue RII interaction domain. Additionally, AKAP-KL binds and regulates the actin cytoskeleton and exhibits a polarized distribution in situ. Thus, AKAP-KL plays a role in establishing polarity in signaling systems and also functions to focus and amplify cAMP-mediated signals by integrating PKA isoforms with downstream effector molecules. |
| 同种亚型 | IgG1 |
| 反应种属 | Mouse (QC Testing) Rat (Tested in Development) |
| 来源宿主 | Mouse |
| 使用方法 | WB, IF |
性能| 供应商 | BD Pharmingen |
| 免疫原 | Mouse AKAP-KL aa. 627-746 |
| 存放说明 | The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.Store undiluted at -20°C.
|
| 存储溶液 | Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide. |
| 浓度 | 250 µg/ml |
