Cdk8 Pure F9-1075 50ug
货号：
552056 基本售价：
3895.0 元 规格：
-
产品信息
概述| 货号 | 552056 |
| 描述 | Cyclins, cyclin-dependent kinases (Cdks), and cyclin-dependent kinase inhibitors (CdkIs) are essential for cell-cycle control in eukaryotes. Cyclins, regulatory subunits, bind to cyclin-dependent kinases (Cdks), catalytic subunits, to form active cyclin-Cdk complexes. Cdk subunits by themselves are inactive and binding to a cyclin is required for their activity. Cyclins A, B1, D and E undergo periodic synthesis and degradation, thereby providing a mechanism to regulate Cdk activity throughout the cell cycle. In contrast to other members of the cyclin family, cyclin C does not have a role in regulating cell cycle progression. Cyclin C and its partner, Cdk8 are associated with RNA polymerase II, an enzyme responsible for transcribing protein encoding genes. Research has shown that Cdk8 stabilizes cyclin C to prevent its degradation, moreover this stabilization exists for either the catalytically active or inactive form of Cdk8. This is in agreement with previous work showing that the kinase activity of the cyclin C - Cdk8 does not change during the cell cycle. |
| 同种亚型 | IgG1 |
| 反应种属 | Dog (QC Testing) Human, Mouse, Chicken (Tested in Development) |
| 来源宿主 | Mouse |
| 使用方法 | WB, Bioimg |
性能| 供应商 | BD Pharmingen |
| 存放说明 | Store undiluted at 4°C.The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
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