Caspase-3 Active Pure C92-605 25ug
货号：
559565 基本售价：
3838.0 元 规格：
-
产品信息
概述| 货号 | 559565 |
| 描述 | The caspase family of cysteine proteases plays a key role in apoptosis and inflammation. Caspase-3 is a key protease that is activated during the early stages of apoptosis and, like other members of the caspase family, is synthesized as an inactive pro-enzyme that is processed in cells undergoing apoptosis by self-proteolysis and/or cleavage by another protease. The processed forms of caspases consist of large (17-22 kDa) and small (10-12 kDa) subunits which associate to form an active enzyme. Active caspase-3, a marker for cells undergoing apoptosis, consists of a heterodimer of 17 and 12 kDa subunits which is derived from the 32 kDa pro-enzyme. Active caspase-3 proteolytically cleaves and activates other caspases, as well as relevant targets in the cytoplasm, e.g., D4-GDI and Bcl-2, and in the nucleus (e.g. PARP). This antibody has been reported to specifically recognize the active form of caspase-3 in human and mouse cells. It has not been reported to recognize the pro-enzyme form of caspase-3. |
| 别名 | CPP32; Yama; Apopain |
| 同种亚型 | IgG |
| 反应种属 | Human (QC Testing) Mouse (Tested in Development) |
| 来源宿主 | Rabbit |
| 使用方法 | IHC(Fr), IP |
性能| 供应商 | BD Pharmingen |
| 免疫原 | Human Active Caspase-3 Fragment |
| 存放说明 | Store undiluted at 4°C.The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
|
| 存储溶液 | Aqueous buffered solution containing ≤0.09% sodium azide. |
| 浓度 | 0.5 mg/ml |
