BAG-1 Pure 19/BAG-1 50ug
货号：
611868 基本售价：
3726.0 元 规格：
-
产品信息
概述| 货号 | 611868 |
| 描述 | Members of the Bcl-2 protein family function to inhibit (Bcl-2, Bcl-XL, Mcl-1, A1) or promote (Bax, Bak, Bcl-Ls, Bad, Bid, Bim, Bik) apoptosis. Bcl-2- associated athanogene-1 (BAG-1) was identified through its interaction with Bcl-2 family proteins. BAG-1 protein has been reported to be expressed as at least three isoforms, 50 kDa (BAG-1L), 46 kDa (BAG-1M/RAP46), and 33 kDa (BAG-1S), which contain conserved C-terminal regions that have an Hsp70-binding domain (HBD). BAG-1M was also identified as RAP46, a protein that binds steroid hormone receptors. BAG1-M is transported to the nucleus along with the ligand-bound glucocorticoid receptor (GR), where it downregulates GR binding to DNA in an Hsp70-dependent manner. In the Hsp70-Hip chaperone system, BAG-1M/RAP46 acts as a negative regulator of Hsp70 chaperone activity, while in the Hsc70-dj systems, BAG-1 acts as a positive cochaperone. BAG-1 mRNA is ubquitously expressed in cells and tissues, while BAG-1L protein is preferentially expressed in many tumor cell lines. Thus, BAG-1 isoforms are multifunctional proteins that may be involved in protein folding, hormone receptor signaling, and malignant transformation. |
| 同种亚型 | IgG1 |
| 反应种属 | Human (QC Testing) |
| 来源宿主 | Mouse |
| 使用方法 | WB |
性能| 供应商 | BD Pharmingen |
| 免疫原 | Human BAG-1 aa. 155-258 |
| 存放说明 | The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.Store undiluted at -20°C.
|
| 存储溶液 | Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide. |
| 浓度 | 250 µg/ml |
