AKAP95 Pure 47/AKAP95 50ug
货号：
610994 基本售价：
3726.0 元 规格：
-
产品信息
概述| 货号 | 610994 |
| 描述 | Induction of cAMP results in the activation of the cAMP-dependent protein kinase (PKA) which, in turn, phosphorylates and regulates downstream effectors. The localization and, hence, the specificity of PKA action is mediated by the interaction of four different PKA regulatory subunits (RIα, RIβ, RIIα, and RIIβ) and specific PKA anchoring proteins. Several proteins have been identified as PKA type I/II anchoring proteins and form a family named AKAP (A-KinaseAnchorProteins). Several AKAPs (AKAP79/75, AKAP350, and AKAP250) associate with PKA type II and direct its localization to cortical actin, centrosomes, and filopodia. AKAP95 is a specific nuclear anchoring protein that contains two zinc finger motifs and an RII binding domain. Although AKAP95 does not interact with RIIβ, it has a high affinity for RIIα. During interphase, AKAP95 is bound to DNA. However, entry into mitosis results in AKAP95 detachment from the DNA and association with RIIα. Although the specific function of this AKAP95/RIIα heterodimer is unknown, its formation is cell cycle-dependent and may be essential for proper progression through the cell cycle. |
| 同种亚型 | Mouse IgG1, κ |
| 反应种属 | Human (QC Testing) |
性能| 供应商 | BD Pharmingen |
| 免疫原 | Human AKAP95 aa. 460-781 |
| 存放说明 | Store undiluted at -20°C.The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
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| 存储溶液 | Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide. |
| 浓度 | 250 µg/ml |
