CD29 Pure 18/CD29 50ug
货号：
610467 基本售价：
3726.0 元 规格：
-
产品信息
概述| 货号 | 610467 |
| 描述 | Integrins are membrane receptors that mediate cell-cell or cell-matrix adhesion. All integrins are transmembrane heterodimers composed of αandβ subunits and are connected to the cytoskeleton. At least 20 integrins, formed from combinations of 12 α and 9 β subunits, have been reported. Many of these have been implicated as transducers of molecular signals. The β 1 subgroup of this receptor family comprises at least six different dimer combinations. Among these combinations, α2β 1 is associated with type I collagen and laminin binding and regulation, α3β 1 is a receptor for laminin and epiligrin, and α5β 1 is a fibronectin receptor. β 1 integrins play an important role in several aspects of epidermal differentiation and morphogenesis. Expression of the β 1 subunit is regulated by growth factors such as TGF- β 1. Integrin activation, which enhances binding of T cells to endothelium, is regulated in part by phosphatidylinositol 3-kinase. Focal adhesion kinase (FAK) and paxillin have been reported to independently bind the C-terminal, cytoplasmic domain of the β 1 subunit. FAK is reported to be enzymatically activated upon engagement of integrins with their ligands and paxillin is phosphorylated on tyrosine upon activation of FAK. |
| 别名 | Integrin β1; platelet GPIIa; VLA β-chain |
| 同种亚型 | IgG1 |
| 反应种属 | Human (QC Testing) Mouse, Rat, Dog, Chicken (Tested in Development) |
| 来源宿主 | Mouse |
| 使用方法 | WB, IHC, IP, IF |
性能| 供应商 | BD Pharmingen |
| 免疫原 | Human CD29 aa. 76-256 |
| 存放说明 | The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.Store undiluted at -20°C.
|
| 存储溶液 | Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide. |
| 浓度 | 250 µg/ml |
