Calcineurin Pure 29/Calcineurin 50ug
货号：
610259 基本售价：
3726.0 元 规格：
-
产品信息
概述| 货号 | 610259 |
| 描述 | Calcineurin is a Ca2+/calmodulin-dependent protein phosphatase. The active enzyme is a heterodimer of a large calmodulin-binding catalytic subunit A (61 kDa) and a smaller Ca2+ binding subunit B (19 kDa). Regions corresponding to the calmodulin-binding site, an autoinhibitory domain, and a putative subunit B binding site have been identified within the large subunit A. The activity of calcineurin is sensitive to immunosuppressants such as cyclosporin A (CsA) and tacrolimus (FK506). The study of FK506-mediated inhibition of nitric oxide formation has revealed that nitric oxide synthase (NOS) is a calcineurin substrate. Calcineurin dephosphorylates NOS and enhances its catalytic activity. Therefore, Calcineurin is an essential mediator for efficient T cell antigen receptor (TCR)-mediated T cell activation. |
| 同种亚型 | IgG2a |
| 反应种属 | Rat (QC Testing) Human, Mouse, Chicken, Frog (Tested in Development) |
| 来源宿主 | Mouse |
| 使用方法 | WB, IHC, IF |
性能| 供应商 | BD Pharmingen |
| 免疫原 | Human Calcineurin aa. 247-449 |
| 存放说明 | The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.Store undiluted at -20°C.
|
| 存储溶液 | Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide. |
| 浓度 | 250 µg/ml |
