Alp-Catenin Pure 5/Alp-Catenin 50ug
货号：
610193 基本售价：
3726.0 元 规格：
-
产品信息
概述| 货号 | 610193 |
| 描述 | The catenins ( α-,β -, and γ -) are cytoplasmic proteins that bind to the highly conserved cytoplasmic tail of E-Cadherin. The cadherins, transmembrane adhesion molecules, are found with catenins at adherens junctions (zonula adherens). These junctions are critical for cell-cell adhesion, signal transmission between neighboring cells, and for the anchoring of the actin cytoskeleton. α -Catenin (CAP102) shows homology to vinculin, while β -Catenin is similar to plakoglobin or the Drosophila armadillo gene product. α -Catenin was identified as an E-Cadherin-associated protein, however, it also appears to interact with other cadherin family members. There are at least two subtypes of α-Catenin:α E-Catenin and α N-Catenin. The predominant form is known as α E-Catenin. It is ubiquitously expressed, but at low levels in the nervous system. The expression of α N-Catenin is more restricted and this form predominates in the brain. Increased tyrosine phosphorylation of adherens junction proteins can disrupt catenin-cadherin complexes, leading to changes in cell adhesion properties. It has been noted that down-regulation of this group of proteins often precedes metastasis. In fact, data suggests a correlation between deletions within the α -Catenin gene and the development of prostate cancer. |
| 同种亚型 | IgG1 |
| 反应种属 | Human (QC Testing) Mouse, Rat, Dog, Chicken (Tested in Development) |
| 来源宿主 | Mouse |
| 使用方法 | WB, IF |
性能| 供应商 | BD Pharmingen |
| 免疫原 | Mouse α-Catenin aa. 729-906 |
| 存放说明 | The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.Store undiluted at -20°C.
|
| 存储溶液 | Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide. |
| 浓度 | 250 µg/ml |
