B-Raf Pure 13/B-Raf 50ug
货号：
612374 基本售价：
3168.0 元 规格：
-
产品信息
概述| 货号 | 612374 |
| 描述 | The Raf kinase family, A-Raf, B-Raf, and C-Raf, act as downstream effectors for Ras. These ser/thr kinases have homologous kinase domains referred to as conserved regions (CR1, CR2, and CR3). Rafs have a critical role in the response to many growth factors including: EGF, PDGF, insulin, IL-2, IL-3, CSF-1, and GM-CSF. Raf can directly interact with Ras-GTP and subsequently become activated. This leads to Raf activation of the MAP kinase pathway by phosphorylating and activating MEK, which then phosphorylates and activates MAP kinaes (ERK). A-Raf is a proto-onocogene that is highly expressed in urogenital and kidney tissues while B-Raf is expressed at high levels in cerebrum and testes. C-Raf appears to be uniformly and ubiquitously expressed. Cell transformation by A-Raf has been shown to be independent of p21ras, suggesting the possibility of an independent signal transduction pathway. B-Raf is expressed as multiple isoforms that range from 69-72 kDa and 79-99 kDa. In hematopoietic cells, B-Raf is activated by EPO, GM-CSF, and SCF. Thus, the Raf kinases are important Ras effectors involved in growth factor signaling in a wide variety of cells and tissues. |
| 同种亚型 | IgG2a |
| 反应种属 | Human (QC Testing) Mouse, Rat (Tested in Development) |
| 来源宿主 | Mouse |
| 使用方法 | WB |
性能| 供应商 | BD Pharmingen |
| 免疫原 | Human B-Raf aa. 285-406 |
| 存放说明 | The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.Store undiluted at -20°C.
|
| 存储溶液 | Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide. |
| 浓度 | 250 µg/ml |
