Rat CD8a IHC Pure OX-8 1mL
货号：
550298 基本售价：
2888.0 元 规格：
-
产品信息
概述| 货号 | 550298 |
| 描述 | The OX-8 antibody reacts with the hinge-like membrane-proximal domain of the 32 kDa α chain of the CD8 differentiation antigen. A truncated CD8 α isoform has not been detected in the rat. The CD8 αandβ chains (CD8a and CD8b, respectively) form a heterodimer on the surface of most thymocytes and a subpopulation of mature T lymphocytes (i.e., MHC class I-restricted T cells, including most T suppressor/cytotoxic cells). Intestinal intrapithelial lymphocytes, many CD8+ T cells of athymic rats, many activated CD4+ T cells, and most NK cells express CD8a without CD8b. It has been suggested that the expression of the CD8a/CD8b heterodimer is restricted to thymus-derived T lymphocytes. OX-8 antibody does not react with resting CD4+ T helper cells. CD8 is an antigen coreceptor on the T-cell surface which interacts with MHC class I molecules on antigen-presenting cells. It participates in T-cell activation through its association with the T-cell receptor complex and protein tyrosine kinase Ick. Macrophages have also been reported to express CD8 αandβ chains, which are involved in signal transduction. Soluble OX-8 mAb partially blocks in vitro MLR and CTL activity. |
| 别名 | Cd8a; CD8α; CD8 alpha; OX-8 membrane antigen |
| 同种亚型 | IgG1,κ |
| 反应种属 | Rat (QC Testing) |
| 来源宿主 | Mouse |
| 使用方法 | IHC(F), IHC(Fr), IHC(Zn) |
性能| 供应商 | BD Pharmingen |
| 免疫原 | High-molecular-weight rat thymocyte glycoproteins |
| 存放说明 | Store undiluted at 4°C.The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
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| 存储溶液 | Aqueous buffered solution containing BSA, goat serum, and ≤0.09% sodium azide. |
| 浓度 | 15.625 µg/ml |
