TBK1 (pS172) Pure J133-1171 100ug
货号：
558397 基本售价：
8436.0 元 规格：
100ug
产品信息
概述| 货号 | 558397 |
| 描述 | NF-k B is a ubiquitously expressed transcription factor that regulates many cytokine and Ig genes. It is involved in immune, inflammatory, viral, and acute phase responses. In most cells, NF- k B is sequestered in an inactive cytoplasmic form via interactions with the inhibitory proteins I kBα , I kBβ , and I kBε . Stimulation induces the release, activation, and nuclear translocation of NF- k B. Release of NF- k B results from the phosphorylation and proteolytic degradation of the I k B proteins. Two cytokine-inducible I κ B kinases (IKK a and IKK b ) phosphorylate and target the I k B proteins for degradation via the ubiquitin pathway. IKK g /NEMO, a third member of the IKK complex, functions as a regulatory subunit and interacts directly with IKK b . TBK1 (TANK-binding kinase 1, also known as T2K or NAK), a protein of 729 amino acids, is another member of the IKK family of kinases regulating NF- k B downstream of the tumor necrosis factor and Toll-like receptor pathways. TBK1 forms a complex with the adaptor proteins TANK (TRAF-associated NF- k B activator) and TRAF2 (TNF-receptor-associated factor 2), and this oligomer is required for activation and phosphorylation of TBK1 at serine 172 (S172). The J133-1171 monoclonal antibody recognizes the phosphorylated S172 of human TBK1. |
| 别名 | T2K, NAK |
| 同种亚型 | IgG2b,κ |
| 反应种属 | Human (QC Testing) Mouse (Predicted) |
| 来源宿主 | Mouse |
| 使用方法 | WB |
性能| 供应商 | BD Pharmingen |
| 免疫原 | Phosphorylated Human TBK1 |
| 存放说明 | The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.Store undiluted at 4°C.
|
| 存储溶液 | Aqueous buffered solution containing ≤0.09% sodium azide. |
| 浓度 | 0.5 mg/ml |
