Tyk2 (pY1054/pY1055) Pure I114-617 100ug
货号：
558394 基本售价：
8436.0 元 规格：
100ug
产品信息
概述| 货号 | 558394 |
| 描述 | Tyk2 is a widely expressed protein tyrosine kinase (PTK) of 1187 amino acids (135 kDa). The N-terminal kinase-related domain of Tyk2 shows 54% identity to the kinase-related domain of the JAK1 kinase. Surprisingly, the catalytic region of JAK1 shares more sequence identity to Tyk2 than it does with JAK2 kinase. The similarity of structure between Tyk2 and JAK1 suggests that both may be involved in related phosphorylation cascades. Tyk2 plays a critical role in the interferon (IFN)- a/b response while JAK1 shows involvement in both the IFN- a/b and IFN- g signal transduction pathways. JAK2, however, appears to be required only in the IFN- g response. It has been suggested that a portion of the large extracatalytic domain of Tyk2 could interact with components of the IFN a/breceptor. The I114-617 monoclonal antibody recognizes the phosphorylated Y1054 and Y1055 in the tyrosine kinase domain of Tyk2. |
| 同种亚型 | IgG1,κ |
| 反应种属 | Human (QC Testing) |
| 来源宿主 | Mouse |
| 使用方法 | WB |
性能| 供应商 | BD Pharmingen |
| 免疫原 | Phosphorylated peptide of the region including the tyrosines 1054 and 1055 of human Tyk2 |
| 存放说明 | The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.Store undiluted at 4°C.
|
| 存储溶液 | Aqueous buffered solution containing ≤0.09% sodium azide. |
| 浓度 | 0.5 mg/ml |
