PDGFR Bta (CD140b) (pY857) Pure 100ug
货号：
558360 基本售价：
8436.0 元 规格：
100ug
产品信息
概述| 货号 | 558360 |
| 描述 | Platelet-derived growth factor (PDGF) is a potent mitogen for cells of mesenchy mal origin and exerts its effects by binding to the PDGF receptor (PDGFR), a transmembrane protein tyrosine kinase. PDGFR is composed of PDGFRα (CD140a) and/or PDGFRβ (CD140b) polypeptides. Both PDGF and PDGFR consist of subunits that form homo- or heterodimers with varying specificities: PDGF-AA binds only to αα PDGFR, PDGF-AB binds to both αα and αβ PDGFR, and PDGF-BB binds to all three PDGFRs. Ligand binding indu ces dimerization and activation of the receptor. Upon activation, CD140b is phosphorylated at multiple tyrosine sites and, in turn, an intracellular phosphorylation cascade is initiated. PDGFR localizes primarily to membrane invaginations termed caveolae , compartments that are enriched in several of its downstream effectors, including phosphatidylinositol 3-kinase, Src, and phospholipase C-γ. The J24-425 monoclonal antibody recognizes the phosphorylated tyrosine 857 (pY857) in the tyrosine kinase domain 2 of CD140b , which is required for maximal receptor kinase activity. The orthologous phosphorylation site in mouse PDGFRβ is Y856. |
| 同种亚型 | IgG1,κ |
| 反应种属 | Mouse (QC Testing) Human (Tested in Development) |
| 来源宿主 | Mouse |
| 使用方法 | WB |
性能| 供应商 | BD Pharmingen |
| 免疫原 | Phosphorylated Human PDGFRβ |
| 存放说明 | The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.Store undiluted at 4°C.
|
| 存储溶液 | Aqueous buffered solution containing ≤0.09% sodium azide. |
| 浓度 | 0.5 mg/ml |
