GSK-3 Bta (pY216) Pure 13A 150ug
货号：
612313 基本售价：
7840.0 元 规格：
150ug
产品信息
概述| 货号 | 612313 |
| 描述 | Glycogen Synthase Kinase-3 β(GSK-3β ) is a serine/threonine kinase that affects glycogen metabolism by phosphorylating and down-regulating the activity of muscle glycogen synthase. GSK-3 β is identical to the Tau Protein Kinase I (TPK I) that plays a role in the formation of the histopathological brain lesions of Alzheimers disease (AD). Phosphorylation of the cytoskeletal protein, tau, by GSK-3 β converts these proteins into paired helical filaments (PHF) which are found in the neurofibrillary tangles and degenerative neurites of AD patients. Regulation of GSK-3 β activity through both serine and tyrosine phosphoylation is a critical determinant of cell death or survival. Factors that promote cell survival, such as growth factors, activate Akt which, in turn phosphorylates GSK-3 β at Ser-9, leading to inactivation of its kinase activity. On the contrary, events that promote cell death, such as growth factor removal, cause increases in phosphorylation within the catalytic domain at Tyr-216 and stimulate kinase activity. Thus GSK-3 β is a tightly regulated death promoting kinase that regulates the activity of various proteins, including cytokeletal and enzymatic proteins. |
| 同种亚型 | IgG1 |
| 反应种属 | Mouse (QC Testing) Human, Rat (Tested in Development) |
| 来源宿主 | Mouse |
| 使用方法 | WB |
性能| 供应商 | BD Pharmingen |
| 免疫原 | Rat GSK-3β (pY216) Peptide |
| 存放说明 | Store undiluted at -20°C.The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
|
| 存储溶液 | Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide. |
| 浓度 | 250 µg/ml |
