Fyn (pY528)/c-Src (pY530) Pure 31 50ug
货号：
612668 基本售价：
5184.0 元 规格：
50ug
产品信息
概述| 货号 | 612668 |
| 描述 | p59fyn is a member of the Src family of protein tyrosine kinases. Two isoforms of the protein have been identified, designated as FynB and Fyn T. Fyn B has been shown to be localized to the brain, whereas Fyn T associates with both B and T cells. Stimulation of the T cell antigen receptor (TcR) results in protein tyrosine phosphorylation via non-receptor tyrosine kinases. p59fyn kinase (Fyn T) associates with the TcR. Ligation of the TcR activates the protein kinase activity of p59fyn in various human T cells. Fyn interacts with the CD3-zeta chains through its N-terminal region. In turn, fyn binds other proteins through its SH2 and SH3 domains. These proteins (p82 and p116) may serve as substrates and/or mediators of fyn activity. p59fyn kinase is tyrosine phosphorylated at two sites, Tyr-417 (autophosphorylation site), and Tyr-528 (negative regulatory site). |
| 同种亚型 | IgG2b |
| 反应种属 | Human (QC Testing) Mouse (Tested in Development) |
| 来源宿主 | Mouse |
| 使用方法 | WB, IC/FC |
性能| 供应商 | BD Pharmingen |
| 免疫原 | Phosphorylated Human Fyn (Y528) Peptide |
| 存放说明 | Store undiluted at -20°C.The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
|
| 存储溶液 | Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide. |
| 浓度 | 250 µg/ml |
