Pyk2 (pY402) Alexa647 L68-1256.272 50Tst
货号：
560256 基本售价：
4655.0 元 规格：
50Tst
产品信息
概述| 货号 | 560256 |
| 描述 | Proline-rich tyrosinekinase2 (Pyk2) is a member of the FAK subfamily of tyrosine protein kinases. Pyk2 responds to a wide variety of inflammatory and stress stimuli, such as cytokines, ligation of integrins or antigen receptors, mechanical strain, and cellular depolarization. A common characteristic of most Pyk2 stimuli is an increase in cytosolic free calcium. Pyk2 is involved in signaling pathways that regulate vital cellular functions in hematopoietic, epithelial, neuronal, endothelial, and other cell types. Activation of Pyk2 initiates its autophosphorylation at tyrosine 402 (Y402), followed by Src-mediated phosphorylation of other Pyk2 tyrosine sites, which enhances its activity and leads to downstream signal transduction through the MAPK and JNK pathways. The L68-1256.272 monoclonal antibody recognizes the phosphorylated Y402 of activated Pyk2. |
| 别名 | Protein tyrosine kinase 2β, FAK2, FADK 2, CAKβ, CADTK, RAFTK |
| 同种亚型 | Mouse BALB/c IgG2b, κ |
| 反应种属 | Human (QC Testing) Rat, Mouse (Predicted) |
性能| 供应商 | BD Pharmingen |
| 免疫原 | Phosphorylated Human Pyk2 Peptide |
| 标记 | Alexa Fluor 647 |
| 存放说明 | Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.The antibody was conjugated to Alexa Fluor® 647 under optimum conditions, and unreacted Alexa Fluor® 647 was removed.
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| 存储溶液 | Aqueous buffered solution containing BSA and ≤0.09% sodium azide. |
