p53 (pS37) Alexa 647 J159-641.79 50Tst
货号：
560280 基本售价：
3920.0 元 规格：
50Tst
产品信息
概述| 货号 | 560280 |
| 描述 | The p53 protein is critical to regulation of normal cell growth and is a suppressor of tumor cell proliferation. Inactivation of p53 by a number of mechanisms, such as missense mutations or interaction with oncogenic viral or cellular proteins, can result in tumor progression. Mutations and/or allelic loss of the p53 gene are associated with a wide variety of human tumors. Known to have a role in transcriptional regulation, p53 suppresses various promoters containing TATA elements in an apparently sequence-independent fashion. p53 also binds to DNA in a sequence-specific manner via recognition of a 20-bp consensus-binding site. This interaction stimulates the expression of genes downstream of the p53 binding site. A number of genes that contain p53-binding sites have been identified, including MDM2, GADD45, and muscle creatine kinase, which primarily prevent cell proliferation. MDM2 mediates feedback inhibition of p53, which is prevented by phosphorylations of p53 amino-terminal serines and threonines. Upon exposure to DNA damage-inducing agents, ATR and DNA-PK (ataxia telangiectasia- and Rad3-related and DNA-dependent protein kinases, respectively) phosphorylate p53 at serine 37 (S37). This phosphorylation disrupts the binding of MDM2 to p53, allowing the cell’s stress responses to proceed. The J159-641.79 monoclonal antibody recognizes p53 phosphorylated at S37. |
| 别名 | TP53 |
| 同种亚型 | IgG1,κ |
| 反应种属 | Human (QC Testing) |
| 来源宿主 | Mouse |
| 使用方法 | IC/FC |
性能| 供应商 | BD Pharmingen |
| 免疫原 | Phosphorylated Human p53 Peptide |
| 标记 | Alexa Fluor 647 |
| 存放说明 | Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.The antibody was conjugated to Alexa Fluor® 647 under optimum conditions, and unreacted Alexa Fluor® 647 was removed.
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| 存储溶液 | Aqueous buffered solution containing BSA and ≤0.09% sodium azide. |
