PKA RII Alp (pS99) PE I65-856.286 50Tst
货号：
560165 基本售价：
3920.0 元 规格：
50Tst
产品信息
概述| 货号 | 560165 |
| 描述 | cAMP-dependentProteinK inase (PKA) is composed of two distinct subunits: catalytic (C) and regulatory (R). Four regulatory subunits have been identified: RI α , RI β , RII α , and RII β . These subunits define type I and II PKAs. Following binding of cAMP, the regulatory subunits dissociate from the catalytic subunits, rendering the enzyme active. Type I and II holoenzymes have three potential C subunits (C α , C β , or C γ ). Type II PKA can be distinguished by autophosphorylation of the R subunits, while type I PKA binds Mg/ATP with high affinity. The cAMP-dependent autophosphorylation of the human RII α subunit occurs at Serine 99 (S99) [Entrez Protein Accession #CAA33094]. Most cells express both type I and type II PKAs. Although the R α isoforms are ubiquitously expressed, the R β isoforms are predominantly found in nervous and adipose tissues. In addition to their enzyme regulatory activity, the RII α and RII β subunits determine the subcellular location of the holoenzymes via their interactions with specific intracellular anchoring proteins. The I65-856.286 antibody recognizes human PKA RIIα phosphorylated at S99. |
| 同种亚型 | IgG1,κ |
| 反应种属 | Human (QC Testing) |
| 来源宿主 | Mouse |
| 使用方法 | IC/FC |
性能| 供应商 | BD Pharmingen |
| 免疫原 | Phosphorylated Human PKA RIIα Peptide |
| 标记 | PE |
| 存放说明 | Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.The antibody was conjugated with R-PE under optimum conditions, and unconjugated antibody and free PE were removed.
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| 存储溶液 | Aqueous buffered solution containing BSA and ≤0.09% sodium azide. |
