p120Catenin(pS268) A647 9a.390 50Tst
货号：
558559 基本售价：
3920.0 元 规格：
50Tst
产品信息
概述| 货号 | 558559 |
| 描述 | The membrane associated protein pp120 Src substrate (p120 catenin, p120cas) was identified as a tyrosine kinase substrate that is phosphorylated in Src-transformed cells. It shares structural similarity with the Drosophila Armadillo protein and the vertebrate b -catenin and g -catenin proteins in its 42-amino acid Arm domain. p120 catenin is localized to the E-Cadherin/catenin cell adhesion complex. Like b - and g -catenin, p120 catenin directly associates with the cytoplasmic C-terminus of E-Cadherin via its Arm domain. It exists as four isoforms that range in size from 90 to 115 kDa. Expression of these isoforms is heterogeneous in human carcinomas, suggesting that altered expression contributes to malignancy. Phosphorylation of multiple serine (S252, S268, S288, and S873), and threonine (T310 and T910) residues in p120 catenin may regulate its activity. The S873 residue is phosphorylated after PKC activation, while the S268 site is dephosphorylated after PKC activation. The latter residue is phosphorylated in vitro by p160 Rock. S252 and T310 residues are phosphorylated in vitro by GSK3b. Thus, p120 catenin function may be regulated in a complex manner through both serine and threonine phosphorylation. The 9a.390 monoclonal antibody recognizes the phosphorylated S268 in the regulatory domain of p120 catenin. |
| 同种亚型 | IgG2b,κ |
| 反应种属 | Human (QC Testing) Mouse, Dog, Monkey (Reported) |
| 来源宿主 | Mouse |
| 使用方法 | IC/FC |
性能| 供应商 | BD Pharmingen |
| 免疫原 | Phosphorylated Human p120 Catenin Peptide |
| 标记 | Alexa Fluor 647 |
| 存放说明 | Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.The antibody was conjugated to Alexa Fluor® 647 under optimum conditions, and unreacted Alexa Fluor® 647 was removed.
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| 存储溶液 | Aqueous buffered solution containing BSA, protein stabilizer, and ≤0.09% sodium azide. |
