Stat2 Pure 22/Stat2 50ug
货号：
610187 基本售价：
3726.0 元 规格：
50ug
产品信息
概述| 货号 | 610187 |
| 描述 | The Stat proteins function as both cytoplasmic signal transducers and activators of transcription. Stat91/84 (the two proteins are the result of alternate splicing-Stat91 has an additional 38 C-terminal amino acids) and Stat113 were the first identified members of this protein family. These three polypeptides contain both SH2 and SH3 domains and have also been described as members of the ISGF3 (interferon-stimulated gene factor 3) complex. With the discovery of additional members of the Stat family (Stats3 & 4), the nomenclature has been revised to indicate the Stat family members in the order of their discovery. Stat 91, 84, and 113 have become Stat1α, Stat1β, and Stat2, respectively. In response to IFN-α treatment, Stat1α, Stat1β, and Stat2 become tyrosine-phosphorylated and migrate to the nucleus where they join a 48 kDa DNA binding protein and subsequently direct the transcription at IFN-α responsive elements. The genes encoding Stat2 and Stat1 are closely related. An extended acidic C-terminal region exclusive to Stat2 implicates a potential role in gene activation. Stat2 phosphorylation can occur independently of Stat1α, but phosphorylated Stat2does appear to be dependent on its interaction with Stat1α for efficient nuclear localization and/or stability. |
| 同种亚型 | IgG2a |
| 反应种属 | Human (QC Testing) |
| 来源宿主 | Mouse |
| 使用方法 | WB, IP |
性能| 供应商 | BD Pharmingen |
| 免疫原 | Human Stat2 aa. 1-178 |
| 存放说明 | The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.Store undiluted at -20°C.
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| 存储溶液 | Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide. |
| 浓度 | 250 µg/ml |
