Stat1 C-terminus Pure 42/Stat1 50ug
货号：
610185 基本售价：
3690.0 元 规格：
50ug
产品信息
概述| 货号 | 610185 |
| 描述 | The Stat proteins function as both cytoplasmic signal transducers and activators of transcription. The Stat91/84 (the two proteins are the result of alternate splicing-Stat91 has an additional 38 C-terminal amino acids) and Stat113 were the first identified members of this protein family. These three polypeptides contain both SH2 and SH3 domains and have also been described as members of the ISGF3 (interferon-stimulated gene factor 3) complex. With the discovery of additional members of the Stat family (Stats3 & 4), the nomenclature has been revised to indicate the Stat family members in the order of their discovery. Stat 91, 84, and 113 have become Stat1 α , Stat1 β , and Stat2, respectively. Stat1 α is present in a higher concentration than Stat1 β in most cell types. In response to IFN α treatment, Stat1 α , Stat1 β , and Stat2 become tyrosine-phosphorylated and migrate to the nucleus where they join a 48kDa DNA binding protein and subsequently direct the transcription at IFN α responsive elements. In IFN- γ treated cells, Stat1 α (but not Stat2) becomes phosphorylated and forms a dimer. It then enters the nucleus and binds to the IFN- γ activated site (GAS) element in order to direct IFN- γ activated transcription. |
| 别名 | C-Terminus |
| 同种亚型 | IgG2b |
| 反应种属 | Human (QC Testing) Mouse, Rat, Dog, Chicken (Tested in Development) |
| 来源宿主 | Mouse |
| 使用方法 | WB, IP, IF |
性能| 供应商 | BD Pharmingen |
| 免疫原 | Human Stat1 aa. 592-731 |
| 存放说明 | Store undiluted at -20°C.The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
|
| 存储溶液 | Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide. |
| 浓度 | 250 µg/ml |
