PLC-Gma2(pY759)Alexa488 K86-689.37 50Tst
货号：
558507 基本售价：
3675.0 元 规格：
50Tst
产品信息
概述| 货号 | 558507 |
| 描述 | ThePhospholipaseC (PLC) isozymes hydrolyze phosphatidyl inositol biphosphate to inositol triphosphate and diacylglycerol. The former causes release of calcium from the endoplasmic reticulum, while the latter is an activator of Protein Kinase C. Within the PLC family, PLC-γ is the only member that contains SH2 and SH3 domains. These domains enable it to interact with protein tyrosine kinases and become enzymatically activated via phosphorylation. It exists as two isoforms: PLC- g 1, which is ubiquitously expressed, and PLC- g 2, which is found primarily in the hematopoietic system. PLC- g 2-null mice exhibit impaired B lymphocyte maturation and defects in Fc receptor functions. Phosphorylation of PLC- g 2 at tyrosines 753 and 759 (Y759) is required for activation of PLC- g 2 enzyme activity. PLC- g 2 phosphorylation at Y759 can be induced by stimulation of the B cell receptor in Ramos cells, the collagen receptor in platelets, and the T cell receptor in Jurkat cells, and it occurs downstream of Btk and BLNK in the signaling cascade of activated B cells. The K86-689.37.73 antibody recognizes PLC- g 2 phosphorylated at Y759 in the SH2-SH3 linker region. |
| 同种亚型 | IgG1,κ |
| 反应种属 | Human (QC Testing) Mouse, Rat (Predicted) |
| 来源宿主 | Mouse |
| 使用方法 | IC/FC |
性能| 供应商 | BD Pharmingen |
| 免疫原 | Phosphorylated Human PLC-γ2 Peptide |
| 标记 | Alexa Fluor 488 |
| 存放说明 | Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.The antibody was conjugated to Alexa Fluor® 488 under optimum conditions, and unreacted Alexa Fluor® 488 was removed.
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| 存储溶液 | Aqueous buffered solution containing BSA and ≤0.09% sodium azide. |
